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Year : 2019  |  Volume : 9  |  Issue : 1  |  Page : 58-63

Bone morphogenetic proteins: Revivifying periodontium

1 Department of Periodontology, School of Dental Sciences, Sharda University, Greater Noida, Uttar Pradesh, India
2 Department of Dental Surgery, Lala Lajpat Rai Medical College and Hospital, Meerut, Uttar Pradesh, India

Correspondence Address:
Dr. Himani Sharma
Department of Periodontology, School of Dental Sciences, Sharda University, Greater Noida - 201 306, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijmd.ijmd_21_19

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Bone morphogenetic proteins (BMPs), a family of signaling molecules, are considered to be a central factor present in the bone matrix. Originally discovered by Urist, they have been shown to affect a wide variety of cell types and processes beyond bone and osteogenesis. They are important morphogens in embryogenesis and development and also regulate the maintenance of adult tissue homeostasis. The loss of alveolar bone is a common consequence of periodontal disease. The regeneration of periodontal structures requires an environment consisting of cells, scaffold, and signaling molecules. The emergence of tissue engineering has enabled the mass production of BMPs, to be utilized refining the biomimetic scaffolds, thus facilitating an alternative to treatment approach in bone regeneration lost due to the disease process. This review discusses the critical data on the discovery of BMPs, its structure, mechanisms of action, and potential therapeutic application in periodontal regeneration.

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