Indian Journal of Multidisciplinary Dentistry

REVIEW ARTICLE
Year
: 2019  |  Volume : 9  |  Issue : 1  |  Page : 58--63

Bone morphogenetic proteins: Revivifying periodontium


Himani Sharma1, Anamika Sharma2 
1 Department of Periodontology, School of Dental Sciences, Sharda University, Greater Noida, Uttar Pradesh, India
2 Department of Dental Surgery, Lala Lajpat Rai Medical College and Hospital, Meerut, Uttar Pradesh, India

Correspondence Address:
Dr. Himani Sharma
Department of Periodontology, School of Dental Sciences, Sharda University, Greater Noida - 201 306, Uttar Pradesh
India

Bone morphogenetic proteins (BMPs), a family of signaling molecules, are considered to be a central factor present in the bone matrix. Originally discovered by Urist, they have been shown to affect a wide variety of cell types and processes beyond bone and osteogenesis. They are important morphogens in embryogenesis and development and also regulate the maintenance of adult tissue homeostasis. The loss of alveolar bone is a common consequence of periodontal disease. The regeneration of periodontal structures requires an environment consisting of cells, scaffold, and signaling molecules. The emergence of tissue engineering has enabled the mass production of BMPs, to be utilized refining the biomimetic scaffolds, thus facilitating an alternative to treatment approach in bone regeneration lost due to the disease process. This review discusses the critical data on the discovery of BMPs, its structure, mechanisms of action, and potential therapeutic application in periodontal regeneration.


How to cite this article:
Sharma H, Sharma A. Bone morphogenetic proteins: Revivifying periodontium.Indian J Multidiscip Dent 2019;9:58-63


How to cite this URL:
Sharma H, Sharma A. Bone morphogenetic proteins: Revivifying periodontium. Indian J Multidiscip Dent [serial online] 2019 [cited 2020 Feb 19 ];9:58-63
Available from: http://www.ijmdent.com/article.asp?issn=2229-6360;year=2019;volume=9;issue=1;spage=58;epage=63;aulast=Sharma;type=0