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REVIEW ARTICLE
Year : 2019  |  Volume : 9  |  Issue : 1  |  Page : 45-48

Role of lipoxins in the resolution of inflammation


Department of Periodontics, A.B Shetty Memorial Institute of Dental Sciences, Nitte (Deemed to be) University, Mangalore, Karnataka, India

Correspondence Address:
Dr. Nina Shenoy
Department of Periodontics, A.B Shetty Memorial Institute of Dental Sciences, Nitte (Deemed to be) University, Deralakatte, Mangalore, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmd.ijmd_38_18

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Periodontal disease is initiated by a group of oral bacteria that stimulate local inflammatory responses, leading to bleeding on probing, loss of periodontal attachment, and bone and ultimately tooth loss. In periodontitis , host bacterial interactions that initiate as an acute inflammatory response develop into a chronic stage which is ruled by macrophages , B-lyphocytes, intense T-Lymphocytes and finally causes the destruction of periodontium. Over the past decade, understanding of pathways of inflammation has matured, and better understanding of the molecular basis of resolution of inflammation has emerged. Resolution of inflammation is an active, agonist-mediated, well-orchestrated return of tissue homeostasis. The mediators that are involved in the resolution of inflammation are lipoxins (LXs), resolvins, maresins, and protectins. This article reviews recent findings and new concepts pertaining to the generation of LXs and their impact on the resolution of inflammation.


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