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Year : 2016  |  Volume : 6  |  Issue : 1  |  Page : 3-6

Evaluation of the serum antioxidant status in patients with chronic periodontitis

1 Department of Periodontics, Himachal Institute of Dental Sciences, Paonta Sahib, Himachal Pradesh, India
2 Department of Oral and Maxillofacial Pathology, HP GDC, Shimla, Himachal Pradesh, India
3 Department of Conservative Dentistry, Government Dental College, Rohtak, Haryana, India

Correspondence Address:
Parveen Dahiya
Department of Periodontics, Himachal Institute of Dental Sciences, Paonta Sahib - 170 325, Himachal Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2229-6360.188213

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Aim: The aim of this study was to evaluate any measurable change in antioxidant and free radical scavenger status in periodontal disease. Materials and Methods: A total of forty subjects consisting of twenty test subjects and twenty controls were recruited for the study. The antioxidant defense status in serum (in terms of superoxide dismutase (SOD), glutathione peroxidase [GSHPx] and catalase [CAT]), serum lipid peroxidation (in terms of malondialdehyde), and free radical scavengers (Vitamin C) was assessed. Results: Significant differences were noted between tests and controls. Negative correlation was observed between the values of lipid peroxidation and that of SOD, GSHPx, and CAT. Our study confirmed that lowered level of SOD, CAT, and GSHPx is associated with hyper lipid peroxidation in periodontal disease. Conclusion: It is now clear that the free radicals play a critical role in the initiation and progression of periodontal disease. Furthermore, the results of the present study may have important therapeutic implications in terms of the use of the antioxidants in periodontal therapy to prevent tissue destruction.

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